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Thegoal of mechanistic studies is to understand the specificbiological reactions (i.e., the adverse chain of events) withinthe affected organism that ultimately result in the toxic effectbeing studied.

More specific tests, including detecting vCJDprions in the CSF, are under development. Cannabis use is most prominently seen within the psychiatricliterature as being associated with detrimental effects on and risks to mental health (e.g. Spontaneous streptococcal arthritis of the pubicsymphysis

Spontaneous streptococcal arthritis of the pubicsymphysis. They are usu-ally located in the connective tissue on the posterior surfaceof the lateral lobes of the thyroid gland (see Fig.

This plasticity allows them to control immuneresponses that would otherwise lead to death via a series of unregulated autoimmuneresponses where vital organs and tissue systems are destroyed.

Note the presence of isogenous groups ofchondrocytes (Ch), a characteristic feature of growing cartilage. The lungs facilitate the exchangeof oxygen and carbon dioxide between the blood and the body cells. Tidal volume in the range of 3–5 mL/kg is generally considered adequate for the neo-nate with lung disease. Figure 3.1 illustrates the structure ofa simple PBPK model for a volatile, lipophilic compound—styrene.

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